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    scientific community to be one of the leading causes of SJS and TEN. A recently published study reported significantly increased risk for ibuprofen in an epidemiologic study published in 2003. (Mockenhaupt, et. al. 2003; Lesko, et. al. 1995.) Anti convulsants and antibiotics are the other leading ca
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    What is Stevens-Johnson Syndrome? Stevens Johnson Syndrome and Toxic Epidermal Necrolysis are life-threatening conditions. Although infrequent, these conditions kill or severely disable previously healthy people. (Roujeau, 1995) Both diseases are characterized by rapidly expanding rashes, often with atypical (flat, irregular) target lesion, and involvement of the mucous membranes (mouth, eyes, and genital areas).

    Risk of getting Stevens-Johnson Syndrome

    Females appear to be twice as affected by SJS and TEN than males. Children taking NSAIDs (Motrin, Advil) and anticonvulsants have recently been reported to have an increased risk of SJS and TEN. (Mockenhaupt, et. al. 2003; Lesko, et. al. 1995.)

    Causes of Stevens-Johnson Syndrome

    Drugs cause over 80% of all cases of SJS / TEN. However, 90-95% of TEN cases are caused only by medications. While there have been very rare reports of infections causing SJS and TEN, most of those case reports were published long before scalded skin syndrome and Toxic Epidermal Necrolysis were distinguished by biopsy, making these cases more likely to have been caused by a drug.

    NSAIDs

    Have recently been recognized by the scientific community to be one of the leading causes of SJS and TEN. A recently published study reported significantly increased risk for ibuprofen in an epidemiologic study published in 2003. (Mockenhaupt, et. al. 2003; Lesko, et. al. 1995.) Anti convulsants and antibiotics are the other leading cau

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    atypical (flat, irregular) target lesion, and involvement of the mucous membranes (mouth, eyes, and genital areas).

    Risk of getting Stevens-Johnson Syndrome

    Females appear to be twice as affected by SJS and TEN than males. Children taking NSAIDs (Motrin, Advil) and anticonvulsants have recently been reported to have an increased risk of SJS and TEN. (Mockenhaupt, et. al. 2003; Lesko, et. al. 1995.)

    Causes of Stevens-Johnson Syndrome

    Drugs cause over 80% of all cases of SJS / TEN. However, 90-95% of TEN cases are caused only by medications. While there have been very rare reports of infections causing SJS and TEN, most of those case reports were published long before scalded skin syndrome and Toxic Epidermal Necrolysis were distinguished by biopsy, making these cases more likely to have been caused by a drug.

    NSAIDs

    Have recently been recognized by the scientific community to be one of the leading causes of SJS and TEN. A recently published study reported significantly increased risk for ibuprofen in an epidemiologic study published in 2003. (Mockenhaupt, et. al. 2003; Lesko, et. al. 1995.) Anti convulsants and antibiotics are the other leading ca

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    recently been reported to have an increased risk of SJS and TEN. (Mockenhaupt, et. al. 2003; Lesko, et. al. 1995.)

    Causes of Stevens-Johnson Syndrome

    Drugs cause over 80% of all cases of SJS / TEN. However, 90-95% of TEN cases are caused only by medications. While there have been very rare reports of infections causing SJS and TEN, most of those case reports were published long before scalded skin syndrome and Toxic Epidermal Necrolysis were distinguished by biopsy, making these cases more likely to have been caused by a drug.

    NSAIDs

    Have recently been recognized by the scientific community to be one of the leading causes of SJS and TEN. A recently published study reported significantly increased risk for ibuprofen in an epidemiologic study published in 2003. (Mockenhaupt, et. al. 2003; Lesko, et. al. 1995.) Anti convulsants and antibiotics are the other leading ca

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    e reports of infections causing SJS and TEN, most of those case reports were published long before scalded skin syndrome and Toxic Epidermal Necrolysis were distinguished by biopsy, making these cases more likely to have been caused by a drug.

    NSAIDs

    Have recently been recognized by the scientific community to be one of the leading causes of SJS and TEN. A recently published study reported significantly increased risk for ibuprofen in an epidemiologic study published in 2003. (Mockenhaupt, et. al. 2003; Lesko, et. al. 1995.) Anti convulsants and antibiotics are the other leading ca

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    scientific community to be one of the leading causes of SJS and TEN. A recently published study reported significantly increased risk for ibuprofen in an epidemiologic study published in 2003. (Mockenhaupt, et. al. 2003; Lesko, et. al. 1995.) Anti convulsants and antibiotics are the other leading causes of these diseases.

    Treatment and Outcomes of patients with Stevens-Johnson Syndrome

    Obviously, the identification of the responsible drug is important so that the causative drug can be withdrawn or the person can be instructed to stop taking it. One study has shown that the mortality rate can be reduced by 30% every day by stopping the drug responsible for the reaction. (Garcia-Doval, 2000) The care of patients with SJS and TEN usually requires that they be placed in a burn unit, which is a highly specialized unit that cares for burn victims with the 2nd and 3rd degree burns that SJS and TEN causes all over the body.

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